ATRA (Tretinoin) + Arsenic Trioxide (Trisenox®) Consolidation is a Chemotherapy Regimen for Acute Promyelocytic Leukemia (APL) How does ATRA + arsenic trioxide work? At diagnosis, APL cells are "trapped" in an immature phase of maturation, do not function normally, and can suppress the growth of good cells in the bone marrow.
Arsenic Trioxide as Effective Therapy for Relapsed Acute Promyelocytic acid ( ATRA) plus anthracycline-based cytotoxic chemotherapy, a combination that is
Here, we systemically synthesized arsenites of all the rare-earth elements, characterized their element-d We examined whether combining all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) might be an alternative to ATRA plus chemotherapy in untreated acute promyelocytic leukemia (APL).Twenty-five low-risk patients (white blood cell [WBC] count less than 10 × 10 9 /L [10 000/μL]) received ATRA (45 mg/m 2 daily) and ATO (0.15 mg/kg daily, beginning day 10 of ATRA), and in complete remission Arsenic Trioxide may be temporarily discontinued in the presence of o Differentiation syndrome (Table 1) o Hepatotoxicity (Table 1) o QT prolongation on ECG (see Arsenic Trioxide and QT prolongation below) Arsenic Trioxide will need to be discontinued permanently in the event of cardiac arrhythmias or severe neurological toxicity. Consolidation therapy of arsenic trioxide alternated with chemotherapy achieves remarkable efficacy in newly diagnosed acute promyelocytic leukemia Cheng-cheng Liu,1-3,* Hua Wang,1-3,* Wei-da Wang,1-3 Meng-yuan Zhu,1-3 Qi-rong Geng,1-3 Yue Lu1-31Department of Hematological Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, People’s Republic of China; 2State Key Laboratory of Oncology Description: Arsenic trioxide, an antineoplastic agent, induces apoptosis by causing morphological changes and DNA fragmentation in acute promyelocytic leukemia (APL) cells.It also damages and degrades promyelocytic leukemia (PML)-retinoic acid receptor (RAR)-α fusion gene, a characteristic of APL. Pharmacokinetics: 1. Nutr Cancer. 2018 May-Jun;70(4):684-696. doi: 10.1080/01635581.2018.1460676.
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It is also used to treat APL in certain people who have not been helped by other types of chemotherapy or whose condition has improved but then worsened following treatment with a retinoid and other types of chemotherapy treatment(s). Arsenic trioxide is in a class of medications called anti-neoplastics. 2021-02-09 2002-07-15 chemotherapy with ATRA plus arsenic trioxide in patients with APL classified as low-to-intermediate risk (white-cell count, ≤10×109 per liter). Patients were randomly assigned to receive either ATRA plus arsenic trioxide for induction and consolidation therapy or standard ATRA–idarubicin induction therapy ATRA (Tretinoin) + Arsenic Trioxide (Trisenox®) is a Chemotherapy Regimen for Acute Promyelocytic Leukemia (APL) How does ATRA + Arsenic Trioxide work? At diagnosis, APL cells are "trapped" in an immature phase of maturation, do not function normally, and can suppress the … The therapeutic advantage of the association of ATRA + Arsenic Trioxide is more favorable and manageable as compared to ATRA + chemotherapy. Nevertheless, at present, there is not enough information on the incidence of long-term side effects.
Efficacy of intratumoral chemotherapy using arsenic trioxide (As2O3) sustained release tablets for the treatment of neurogliocytoma in nude mice. Eur Rev Med Pharmacol Sci Year: 2014 Vol. 18 - N. 17 . Pages: 2453-2459
Drug type: Arsenic Trioxide is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy … Annals of Oncology 14: 752–757, 2003 Original article DOI: 10.1093/annonc/mdg208 Arsenic trioxide in comparison with chemotherapy and bone marrow transplantation for the treatment of relapsed acute promyelocytic leukaemia W. Y. Au1, A. K. W. Lie1, C. S. Chim1, R. Liang1, S. K. Ma2, C. H. Chan3, Y. K. Mak3, Y. T. Chen3, C. C. So4, Y. M. Yeung5, S. F. Yip5, L. G. Wong5, J. C. Chan6, S. Y. Liu6 Differentiation Syndrome: Patients with acute promyelocytic leukemia (APL) treated with TRISENOX ® (arsenic trioxide) injection have experienced symptoms of … Arsenic trioxide was infused at 0.15 mg/kg daily dose, until complete remission was achieved. Then, after 28 days of rest, arsenic trioxide was infused daily for 28 days as consolidation therapy.
among patients with chemotherapy treatment for advanced colorectal cancer. Molin Y., P Frisk, N-G Ilbäck. Sequential effects of daily arsenic trioxide treatment
Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. N Engl J Med 1998;339(19):1341-48. 2. Estey E, Garcia-Manero G, Ferrajoli A, et al. Use of all-trans retinoic acid plus arsenic trioxide as an alternative to chemotherapy in untreated acute promyelocytic leukemia. Blood 2006;;107(9 Arsenic trioxide (ATO) is approved for the treatment of acute promyelocytic leukaemia and is under investigation for other malignancies.
Drugs used in chemotherapy, such as tretinoin and arsenic trioxide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Gemtuzumab ozogamicin is a monoclonal antibody, called gemtuzumab, linked to a chemotherapy drug called ozogamicin. Arsenic trioxide has shown substantial efficacy in treating both newly diagnosed and relapsedpatients with acute promyelocytic leukemia (APL). As a single agent, it induces complete remissions, causing few adverse effects and only minimal myelosuppression. These successes have prompted investigations to elucidate the mechanisms of action underlying these clinical responses. Substantial data
chemotherapy, 43% for chemotherapy and BMT and 82% for chemotherapy plus arsenic trioxide (p = 0.0004).
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Feb 6, 2017 CHEMOTHERAPY INDUCED CARDIOTOXICITY Dr. VISHAL VANANI ARSENIC TRIOXIDE • Arsenic is commonly known to cause ECG Oct 9, 2020 To find the correct oxidation state of As in As2O3 (Arsenic trioxide), and each element in the molecule, we use a few rules and some simple Sep 13, 2019 The Bari bombing was not the key to the development of chemotherapy. That dubious “credit” goes to the 1917 mustard gas attack at Ypres.
ARSENIC TRIOXIDE During Induction, Arsenic Trioxide may be temporarily discontinued in the presence of Differentiation syndrome, QT prolongation on ECG or Hepatotoxicity; the drug will need to be discontinued permanently in the event of cardiac arrhythmias or severe neurological toxicity. Toxicity of Grade 3 or greater
Experimental group receive arsenic trioxide combined with induction chemotherapy while control group receive conventional induction chemotherapy alone. The 3 year overall survival rate (OS) and progression free survival (PFS), as well as incidence of adverse events, will be compared between two groups.
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Efficacy of intratumoral chemotherapy using arsenic trioxide (As2O3) sustained release tablets for the treatment of neurogliocytoma in nude mice. Eur Rev Med Pharmacol Sci Year: 2014 Vol. 18 - N. 17 . Pages: 2453-2459
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